Relation between Human Papilloma Virus Infection and Spontaneous Miscarriage

  • Nada Salih Ameen, Israa Talib Abd Al Kadir, Noora Kamal Jassim
Keywords: Miscarriage, high risk human papillomavirus (hrHPV), Pregnancy.




Approximately one in four women will have an early pregnancy failure during her lifetime.                   In pregnant women or in their partners, human papillomavirus infection can be considered as a risk of preterm birth, miscarriages and virus transmission to the newborn.


To disclose the prevalence of high risk human papillomavirus infection in women suffering             from spontaneous miscarriage .


A case - control study included 100 pregnant women ,age (20-42 years old) ,50 full term pregnant )Gestation age 37-40 week) delivered viable full term pregnancy, and 50 pregnant women experienced spontaneous miscarriage (Gestation age 8-24week), cervical swab was done in                 the labor ward of Al-Yarmouk Teaching Hospital from all participants, and the samples were taken to a private lab for high risk human parvovirus  detection. The study period was from 1st of March to 30th of November 2017.


The overall prevalence of high risk human papillomavirus  is 7%, the highest proportion of study patients with high risk human papillomavirus infection ended with miscarriage (71.4%), while in those with viable full term pregnancy were (28.6%). A number of risk factors which increased prevalence of high risk human papillomavirus hrHPV infection were detected as previous history of miscarriage, smoking, and history of oral contraceptives use.


High risk human papillomavirus  prevalence was higher in pregnancy with spontaneous miscarriage compared to women experience a normal full term pregnancy.